Marfan syndrome is a heritable disorder. It specifically affects the connective tissue. The main purpose of the connective tissue is to bind the body’s structures together. In marfan syndrome, the connective tissue becomes defective and does not act accordingly. Marfan syndrome can affect many body systems as connective tissue is found throughout the body.
Marfan syndrome affects women, men and children. It has been found that it affects people of all races and at least 1 in 5,000 people in the United States.
There are several eye conditions which are commonly seen in people with Marfan syndrome as well as the general population. But some eye conditions like dislocated lenses are rarely seen in the general population.
Some conditions which are common among persons with Marfan syndrome are mentioned below:
- flattened corneal curvature
- high refractive error
- glaucoma
- early onset cataracts
- strabisums
- retinal detachments
Most people with Marfan Syndrome have astigmatism (visual distortion) and they are myopic (near sighted). It is estimated that approximately 65% of people afflicted with this syndrome have dislocated lens (ectopia lentis). Dislocated lenses is a strong indication of Marfan syndrome. It needs further medical attention.
Evaluation is done using a slit lamp to identify the lens dislocation. It is often seen that in middle age, cataract forms in the eye with this disorder. Also retinal detachment is commonly found in people with the disorder. About 35% of people with Marfan syndrome may develop glaucoma during their lifetime.
The first sign experssed in a person with Marfan syndrome is a dislocated lens. It may severely affect the visual development and function. Therefore, annual ophthalmic examinations are encouraged. This may include evaluation of the peripheral retina, refraction and intraocular pressure measurement.
